Gaeta Therapeutics

Turning cold tumours hot with IL12

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Whilst checkpoint blockade has had considerable clinical and commercial success, monotherapy remains unsuccessful in the majority of cancer types and patients. Local delivery or expression of IL-12 increases tumour immunogenicity, which is then amenable to treatment. The synergy between IL-12 and checkpoint blockade has been shown to permit the treatment of cancer types and patient groups, which have hitherto been non-responsive to conventional immunotherapy. Gaeta’s patent portfolio protects the use of locally delivered IL-12, whether through protein/fusion protein, nucleic acid or oncoviral expression, in combination with CTLA4, PD1 or PDL1 checkpoint Blockade.

Team

  • Adam Levy
  • Prof. Burkhard Becher
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