Turning cold tumours hot with IL12
Whilst checkpoint blockade has had considerable clinical and commercial success, monotherapy remains unsuccessful in the majority of cancer types and patients. Local delivery or expression of IL-12 increases tumour immunogenicity, which is then amenable to treatment. The synergy between IL-12 and checkpoint blockade has been shown to permit the treatment of cancer types and patient groups, which have hitherto been non-responsive to conventional immunotherapy. Gaeta’s patent portfolio protects the use of locally delivered IL-12, whether through protein/fusion protein, nucleic acid or oncoviral expression, in combination with CTLA4, PD1 or PDL1 checkpoint Blockade.
- Adam Levy
- Prof. Burkhard Becher